Endocrine Abstracts

Objective: Acromegaly is associated with increased cardiovascular mortality. Hyperhomocysteinemia has been associated with cardiovascular disease, lower-extremity peripheral arterial disease and heart failure. Data on the prevalence of hyperhomocysteinemia and peripheral arterial disease in patients with acromegaly is still limited. The aim of this study was to compare serum homocysteine levels between acromegaly patients with active disease and remission, and to evaluate pres...

Objective: To evaluate the presence of glucose metabolism abnormalities and their impact on IGF-1 levels in patients with acromegaly.Methods: Ninety-three acromegalic patients (52 male/41 female) were included in this study who were seperated into three groups as normal glucose tolerance (NGT), prediabetes and diabetes mellitus (DM). Insulin resistance (IR) was calculated with homeostasis model assessment (HOMA). HOMA-IR >2.5 or ≤2.5 were defin...

Objective: The aim of the study is to evaluate both the long-term consequences of exposure to dopamine agonists (CAB and BRC) at the beginning and during pregnancy, and the effects of pregnancy on remission.Methods: Thirty-seven prolactinoma patients who developed 58 pregnancies while receiving DAs treatment were included in this retrospective study. Age of gestation; both maximum residual tumor diameter and PRL levels before conception; the course of pr...

Purpose: Somatotrophinomas have been shown to demonstrate T2-weighted signal intensity (WSI) on MRI that is correlated with clinicopathological findings and response to treatment. Therefore, we aimed to investigate these correlations in functional pituitary adenomas, including prolactinoma and corticotrophinoma. Material and MethodsPatients with somatotrophinoma (n=87), prolactinoma (n=78) and corticotrophinoma (n=33) were invo...

A 41-year-old woman was admitted with headache and hypertension. She described worsening of headaches in the last 2 months. On physical examination blood pressure was 150/90 mmHg, and grade 1 hypertensive retinopathy was present. Her sister died at the age of 24 due to pancreas neuroendocrine tumour and her mother was followed up with multiple pancreatic cysts. Abdomen MRI revealed a 6 cm phaeochromocytoma lesion on the right surrenal and multiple cysts in the pancreas, kidney...

Propylthiouracil (PTU) is a widely used drug, and can cause drug-induced vasculitis which is characterized by inflammation and cellular infiltration of small vessels and presence of anti-neutrophil cytoplasmic antibodies (ANCA). We report a case of perinuclear antineutrophil cytoplasmic antibody-associated vasculitis developed during treatment with PTU for Graves’ disease. A 58-year-old woman admitted to the Emergency Department with painful necrotic lesion at her right e...

Oncogenic osteomalacia is a rare paraneoplastic syndrome, which can be associated with phosphaturic mesenchymal tumor or non-mesenchymal tumour. This tumour produces fibroblast growth factor 23 (FGF-23) that leads to subsequent hypophosphataemic osteomalacia. We, hereby present a patient with oncogenic osteomalasia who is misdiagnosed as ankylosing spondylitis. A 54-year old man with weakness, severe arthralgia involving pelvis, hip joints and lower extremities referred to the...

Introduction: Dopamine agonists (DAs) consisting of cabergoline (CAB) or bromocriptine is the primary therapy in prolactinomas. DAs are also used in Parkinson’s disease and restless leg syndrome with much higher doses. As a result of reports related to doses in these patients, it is known that long term use of DAs can lead to fibrotic syndromes affecting heart and lung. Cardiac valvulopathies are the most common investigated side effects but there are case reports of ple...

Introduction: Schwachman–Diamond syndrome (SDS) is usually manifested with exocrine pancreatic insufficiency, short stature, and chronic neutropenia. SDS associated with osteoporosis and diabetes mellitus (DM) presenting with ketoacidosis is quite rare.Case: A 29-year-old woman was admitted to emergency room with symptoms of frequent urination and confusion. She had not history of diabetes mellitus or any other disease. On her examination, she had n...

Aim: To determine the prevalence of impulse control disorder (ICD) in patients with Cushing’s disease (CD) treated with cabergoline (CBG) compared to CBG-naive patients with CD.Methods: We performed a cross-sectional study in patients with CD followed at 5 referral centers based in Istanbul. Eligible patients with CD were those with current CBG treatment for ≥ 3 months. Eligible controls were CBG-naive patients with CD that were matched for ag...